# San Francisco 49ers vs Indianapolis Colts: Score, Stats & Preview |NFL

> San Francisco 49ers at Indianapolis Colts. Final. Margus compares prices and does not take bets.

Canonical: https://margus.app/sports/football/nfl/games/2025-12-22/san-francisco-49ers-indianapolis-colts

## Score

San Francisco 49ers 48, Indianapolis Colts 27

## Odds

- [Every book’s prices and line history](https://margus.app/odds/nfl/2025-12-22/san-francisco-49ers-indianapolis-colts)