# San Francisco 49ers vs Indianapolis Colts Odds | NFL | Dec 22, 2025

> San Francisco 49ers at Indianapolis Colts (NFL) is final on 2025-12-22. Final: San Francisco 49ers 48, Indianapolis Colts 27. Kickoff and team links are below. Stored moneylines, spreads, and totals are not posted yet. Margus does not take bets.

Canonical: https://margus.app/odds/nfl/2025-12-22/san-francisco-49ers-indianapolis-colts

## San Francisco 49ers at Indianapolis Colts

NFL. Final. Mon, Dec 22, 8:15 PM EST. Final: San Francisco 49ers 48, Indianapolis Colts 27

## Moneyline, spread, and total

No eligible sportsbook prices are stored yet.